ceesdekker.net - An Overview

ceesdekker.net - An Overview

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2009, discovery of a new phenotype for microorganisms in slim nanofluidic slits; and 1st detection of community protein buildings together DNA working with good-point out nanopores

1996, initially mesoscopic charge density waves units; and initially electrical measurements on a single steel nanocluster concerning nanoelectrodes

Around the exact time, the team of Paul McEuen, who was then primarily based within the College of California, Berkeley, showed identical effects on ropes of bundled nanotubes. According to the wrapping angle, nanotubes can come in metallic or semiconducting variants, a prediction that we and Charles Lieber’s team at Harvard University independently verified utilizing scanning tunnelling spectroscopy experiments.

I can hardly consider how I, for a geneticist, would manage to study fundamental physics, not to mention contend at the very best. How did you go about this?

2010, made a fresh way (‘wedging transfer’) to manipulate nanostructures; very first report of DNA translocation by way of graphene nanopores; and understood hybrid nanopores by directed insertion of α-hemolysin into sound-condition nanopores

SMC complexes can move Bodily roadblocks bigger than their ring dimension, indicating a nontopological mechanism for DNA loop extrusion

We form microbes into varieties that deviate from their normal phenotype. Exclusively, I will display our power to shape Reside E. coli germs into novel shapes which include rectangles, squares, triangles and circles.

2000, discovery that nanotubes can have incredible substantial recent densities; solved the controversial issue of electronic transportation by means of DNA molecules by measurements of insulating behavior at The one molecule degree; and demonstration of an AFM system for single-molecule manipulation of nanotubes

Comprehending basic processes regulating the spatial and dynamic organisation from the DNA in Reside cells.

‘The fantastically delicate way wherein things in character operate never ever ceases to amaze me. If we remedy the puzzle of how lifestyle arrived into remaining, I be expecting that my amazement with the complexity of creation will have amplified and with it my awe for that greatness on the Creator.’

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Cees Dekker is Distinguished College Professor at TU Delft. Experienced for a physicist, he pioneered nanotechnology with lots of discoveries on carbon nanotubes in the 1990s. Since 2000, he moved to single-molecule biophysics https://www.ceesdekker.net and nanobiology. His present study focuses on (i) nanopores for protein sequencing; (ii) chromosome composition, especially SMC motor protein; and (iii) developing a residing synthetic cell from lifeless molecules. Dekker is definitely an elected member in the KNAW and fellow towards the APS and also the IOP.

2008, very first observation of protein-coated DNA translocation by means of nanopores; settled the origin in the electrophoretic power on DNA in nanopores; uncovered a big velocity maximize of microtubules in electrical fields; identified an anomalous electro-hydrodynamic orientation of microtubules; and settled the origin of noise in carbon nanotubes in liquid

2013, controlled shaping of live bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations in the handedness of histone tetrasomes